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EpigenesisWorkshops

PROGRAMME D'ÉPIGÉNOMIQUE - GENOPOLE ®

ATELIER ÉPIGENÈSE


mercredi 24 juin 2009

10h00 – 17h00 : NEWSYNBIO
14h00 – 17h00 : SMABio-Hyperstructures

jeudi 25 juin 2009 Session Publique

09h30 – 10h00 : Accueil
10h00 – 10h15 : Présentation par le groupe SMABio :
10h15 – 11h15 : Francisco Monroy, Fac. Química, Universidad Complutense de Madrid, "Membrane elasticity : a plausible mechanism for signal transmission ?"
11h15 – 11h30 : Pause
11h30 – 12h00 : Nicolas Parisey "Modeling spatial behaviors of microscopic biological systems using Multi-Agents Systems"
12h00 – 12h30 : Guillaume Hutzler
12h30 - 13h00 : Discussion
13h00 – 13h15 : Présentation de la Session publique suivante GolgiTop
13h15 – 14h00 : Déjeuner

14h00 Fin de la séance publique

14h00 – 17h00 : SMABio-Hyperstructures
14h00 – 17h00 : Observabilité
14h00 – 17h00 : NEWSYNBIO
16h00 – 18h00 : Réunion du comité scientifique de l'école de Printemps : EVRY'10 THEMATIC RESEARCH SCHOOL

vendredi 26 juin 2009

09h30 – 10h00 : Accueil
10h00 – 15h00 : Bioputing
10h00 – 17h00 : GolgiTop

Membrane elasticity : a plausible mechanism for signal transmission ?

Francisco Monroy Universidad Complutense, Madrid, Spain

The great success of allostery concept in describing the propagation of conformational changes through extended lattices of protein molecules has stimulated new hypotheses on the mechanisms of signal transmission in cell membranes [2]. Lipid conformational spread has been invoked as a plausible mode of transmission of a local event to a remote location in the membrane. However, lateral lipid diffusion is revealed too slow, thus inefficient, in transmitting mechanical information over long distances. Mechanical signals can be however efficiently propagated as traveling waves through the membrane, understood as a continuous elastic medium. In this seminar we will review the basic concepts of membrane mechanics essential to understand how far and how fast a mechanical disturbance propagates along a lipid bilayer. This continuous approach will be discussed as a possible functional mode of operation for the remote transport of conformational/mechanical information in biological membranes.\\

References
[1] Conformational spread: The Propagation of Allosteric States in Large Multiprotein Complexes, D. Bray et al, Annu. Rev. Biophys. Biomol. Struct. 33, 53 (2003)
[2] Heightened sensitivity of a lattice of membrane receptors, T. A. J. Duke and D. Bray, PNAS 96, 10104 (1999)¶

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